8-OH-HHC: Discover a new cannabinoid with the gentle energy of the jungle!

- What is 8-OH-HHC?
- How are commercially available 8-OH-HHC products made?
- Mapping the stereoisomers and structure of 8-OH-HHC
- How does 8-OH-HHC work?
- Canntropy 8-OH-HHC products worth exploring
- The end of the adventure
What is 8-OH-HHC?
8-hydroxyhexahydrocannabinol is short for 8-OH-HHC, it is a hydroxy derivative of HHC. The cannabinoid 8-OH-HHC is representative of a fascinating group of chemical compounds, which includes, for example, 8-OH-9α-HHC and 8-OH-9β-HHC. These substances are distinguished from other cannabinoids by their unique chemical structure and properties.
8-OH-HHC is like a rare ocelot that moves silently in the jungle of cannabinoids 🐆. It's presence is subtle, hard to spot, yet it is an essential part of the rainforest ecosystem.
Finding 8-OH-HHC is not easy 🔎 as it is supposedly a trace phytocannabinoid, which means that it is only found in minute amounts in the cannabis plant. And although nature "doses it sparingly", its importance is greater than it may seem at first glance, as it is also one of the so-called primary metabolites of hexahydrocannabinol (HHC).
This brings us to why 8-OH-HHC is so interesting and unique. The answer lies within the organism, whether human or animal, where this compound is produced as the active form of HHC. Once HHC enters the body, for example by vaporization or other means, specific biochemical processes are triggered in the body.
Special enzymes belonging to the cytochrome P450 group, namely CYP3A4, CYP2C9 and CYP2C19, are responsible for these processes - they add oxygen to the HHC structure and convert (metabolise) it into new substances called oxygen derivatives.
The same mechanism of transformation works for other known cannabinoids such as delta-9-THC (tetrahydrocannabinol, THC) and delta-8-THC.8-OH-HHC is one of the most important derivatives of this type, but it is far from the only one. Others include, for example, 10-OH-HHC.
How are commercially available 8-OH-HHC products made?
8-OH-HHC is produced by synthesis from HHC, the key step being hydroxylation 🔬. In this process, scientists add a hydroxyl group (OH) at the 8th carbon of the hexahydrocannabinol nucleus - this process is known as hydroxylation at the 8th carbon (C8). In the case of the 10-OH-HHC compound, a hydroxyl group is added at the 10th position.
To form 8-OH-HHC, scientists use either enzymes or chemical catalysts that modify the HHC and allow a hydroxyl group (-OH) to be attached. The group can be attached to different parts of the molecule, resulting in different stereoisomers.
For 8-OH-HHC, stereoisomers such as 8-OH-9α-HHC and 8-OH-9β-HHC are typical. The method of synthesis is chosen according to which stereoisomer is desired in a particular product.
Stereoisomer and structure mapping of 8-OH-HHC
The molecular formula of 8-OH-HHC is C21H32O3, i.e. 21 carbon atoms (C), 32 hydrogen atoms (H) and 3 oxygen atoms (O).
There are 4 main forms (stereoisomers) of the compound 8-OH-HHC, which differ from each other by minor changes in structure. The stereoisomers are designated cis- and trans-8-OH-9α-HHC and cis- and trans-8-OH-9β-HHC. They are all the product of synthetic processes and were first targeted by scientists in the 1980s to discover how these variants affect the biological activity of cannabinoids.
Another groundbreaking study came in 1991, when chemist Raphael Mechoulam and his team conducted in vivo tests on rhesus macaques. These experiments suggested that the stereoisomer cis-8-OH-9β-HHC had the highest activity, although all 4 forms are thought to have some biological activity.
At the same time, it has been shown that different animal species may respond differently to 8-OH-HHC. Earlier studies have suggested that, for example, mice 🐭 form a particular form of 8-OH-HHC more than hamsters 🐹.
How does 8-OH-HHC work?
8-OH-HHC has psychoactive effects and can subtly alter perception, bring a hint of euphoria, relaxation and awaken the appetite.
However, compared to HHC or THC, it has a milder effect due to the fact that it is a hydroxy derivative - in general, hydroxy derivatives have lower bioavailability and break down quickly in the body. The effects will therefore be less intense and will wear off in a shorter period of time.
Like other cannabinoids, 8-OH-HHC most likely binds to CB1 and CB2 receptors in the body's endocannabinoid system (ECS).
However, it is important to add that scientific understanding of this compound is still in its infancy. So far, there are no studies that have accurately mapped the effects of 8-OH-HHC or its interaction with ECS.
Wilderness traps: what are the potential side effects?
Commonly recognised side effects for cannabinoids with psychoactive properties include:
- Dry mouth
- Red and dry eyes
- Drowsiness or insomnia
- Increased heart rate
- Anxiety and paranoia
- Dizziness
The list of these effects is based on experience with other cannabinoids such as HHC, HHCP, THCP, THCB and THCJD. Their intensity will vary depending on the health status, metabolism and sensitivity of the explorer, dose and method of consumption.
Canntropy 8-OH-HHC products worth exploring
With our 8-OH-HHC products, you're in for a journey of discovery 🌴. Already know what you want to try? ⬇️
- 8-OH-HHC Vapes: vape pens are ready for immediate use, it's simple and discreet.
- 8-OH-HHC Liquids: Vape juice for those who want to venture up into the fragrant clouds ☁️.
- Cartridges: cartridges pre-filled with 8-OH-HHC distillate (liquid) simply need to be connected to a vaporizer or battery.
- 8-OH-HHC Hash: A concentrated form of 8-OH-HHC that can be vaped through a vaporizer or dab rig.
- PreRolls: pre-packaged joints are full of flowers containing 8-OH-HHC.
- 8-OH-HHC Flowers: technical cannabis flowers infused with 8-OH-HHC infused with terpenes from different cannabis varieties, e.g. Girl Scout Cookies 🍪
- Oils: The oil contains a 10% concentration of 8-OH-HHC and is blended with a carrier oil, MCT coconut oil 🥥 , ideal for sublingual application or oral use.
- Gummies: sweet chewy candies in a fruity mix containing the cannabinoid 8-OH-HHC, a playful and popular way to enjoy this cannabinoid
All products contain less than 0.2% THC and therefore meet the legislative requirements of the European Union.
Explorers, remember that in the wilderness of cannabis products, having a reliable guide is key, always choose verified and trusted companies.
The end of the adventure
8-hydroxyhexahydrocannabinol is a hydroxyderivative of HHC, reportedly a trace phytocannabinoid that is also one of the so-called primary metabolites of the cannabinoid HHC. Commercially available 8-OH-HHCs are formed by synthesis from HHC by attaching a hydroxyl group (-OH) to the 8th carbon of the molecule.
8-OH-HHC has psychoactive effects, and compared to the cannabinoids HHC and THC, the effects are milder and wear off more quickly.
8-OH-HHC is another of the treasures hidden in the cannabis jungle 🌴. Whether you're going to explore its effects 🔍 or you're just gathering information about this novelty, you won't get bored on this trip ✨!
Author: Patricie Mikolášová
Photo: AI
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